Playable (with major caveats) on Yuzu (Mainline/Early Access builds) and its fork Suyu (since Yuzu development was discontinued).
Here's a direct, factual answer based on the current emulation status: skylanders imaginators yuzu
I understand you're asking about running Skylanders: Imaginators on the emulator (Nintendo Switch emulation for PC/Android). Playable (with major caveats) on Yuzu (Mainline/Early Access